Short papers Nitric oxide and prostacyclin as test agents of vasoreactivity in severe precapillary pulmonary hypertension: predictive ability and consequences on haemodynamics and gas exchange
نویسندگان
چکیده
may make it a more appropriate agent for testing the vasodilator response. Background – In patients with primary (Thorax 1997;52:369–372) pulmonary hypertension who respond to vasodilators acutely, survival can be im
منابع مشابه
Nitric oxide and prostacyclin as test agents of vasoreactivity in severe precapillary pulmonary hypertension: predictive ability and consequences on haemodynamics and gas exchange.
BACKGROUND In patients with primary pulmonary hypertension who respond to vasodilators acutely, survival can be improved by the long term use of calcium channel blockers. However, testing for such a response with calcium channel blockers or prostacyclin (PGI2) may cause hypotension and adversely affect gas exchange. Nitric oxide (NO), which does not have these effects, could be a better test ag...
متن کاملTissue responses to ischemia
Exposure of most animals to low levels of environmental oxygen results in alveolar hypoxia and reliably causes chronic pulmonary hypertension and morphological alterations of the precapillary pulmonary vessels (1–4). Chronic hypoxic exposure of animals has been used for decades to induce pulmonary vascular remodeling and, more recently, to assess the roles in this process of lipid mediators (5)...
متن کاملThalassemia Associated Pulmonary Hypertension
Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...
متن کاملCardiopulmonary effects of iloprost in experimental acute lung injury.
Iloprost, a prostacyclin analogue with a prolonged plasma half-life has beneficial effects in chronic pulmonary hypertension, whereas the effects in acute lung injury (ALI) are unknown. The present study was performed to evaluate the cardiopulmonary effects of iloprost in experimental ALI. ALI was induced in 18 pigs by repeated lung lavage. Animals were randomised to controls, i.v. or inhaled i...
متن کاملEditorial Adrenomedullin in the treatment of pulmonary hypertension
Pulmonary hypertension is seen in patients in whom there is an increased pulmonary pressure (systolic pulmonary/ systemic arterial pressure > 60%; > 15–20 mm Hg). The disease slowly progresses, applying stress on the right heart function leading to heart failure and death. Although the precise mechanism of development of precapillary pulmonary hypertension remains to be defined, understanding o...
متن کامل